Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure
Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF).Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF.cAMP signals are received and integrated by a family of cAMP-dependent pro